Histone chaperone

Functions

Implication in disease

Reference number

Asf1

Histone import, histone transfer to CAF-1 and HIRA, regulation of H3K56ac

Increased in breast cancer

28, 31, 44, 58

CAF-1

H3.1-H4 deposition, heterochromatin formation, repair

Increased in renal, endometrial and cervical cancer

12, 33, 46, 59

DAXX

H3.3-H4 deposition at telomeric heterochromatin

Mutated in pancreatic neuroendocrine and glioblastoma

55, 56, 68

DEK

H3.3-H4 deposition, maintenance of heterochromatin

DEK-CAN fusion due to chromosomal translocation in AML

55, 57, 66, 67

NASP

H1 and H3/H4 supply and turnover

Increased in prostate cancer

11, 60

NPM

H1 and H3/H4 deposition, ribosome assembly, genomic stability

Mutated in AML patients

18, 64, 65

FACT

H2A/H2B deposition, Transcription

Increased during metastasis of breast, renal, and prostate cancer

7, 61, 62, 63