Histone chaperone | Functions | Implication in disease | Reference number |
Asf1 | Histone import, histone transfer to CAF-1 and HIRA, regulation of H3K56ac | Increased in breast cancer | 28, 31, 44, 58 |
CAF-1 | H3.1-H4 deposition, heterochromatin formation, repair | Increased in renal, endometrial and cervical cancer | 12, 33, 46, 59 |
DAXX | H3.3-H4 deposition at telomeric heterochromatin | Mutated in pancreatic neuroendocrine and glioblastoma | 55, 56, 68 |
DEK | H3.3-H4 deposition, maintenance of heterochromatin | DEK-CAN fusion due to chromosomal translocation in AML | 55, 57, 66, 67 |
NASP | H1 and H3/H4 supply and turnover | Increased in prostate cancer | 11, 60 |
NPM | H1 and H3/H4 deposition, ribosome assembly, genomic stability | Mutated in AML patients | 18, 64, 65 |
FACT | H2A/H2B deposition, Transcription | Increased during metastasis of breast, renal, and prostate cancer | 7, 61, 62, 63 |